Abstract
The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.
MeSH terms
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AIRE Protein
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Amino Acid Motifs / genetics
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Animals
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Antigens / biosynthesis
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Antigens / chemistry
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Antigens / genetics*
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Conserved Sequence / immunology
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Gene Expression Regulation / immunology*
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Humans
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Immune Tolerance / genetics
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Mice
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Mice, Knockout
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Polyendocrinopathies, Autoimmune / genetics
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Polyendocrinopathies, Autoimmune / immunology
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Polyendocrinopathies, Autoimmune / metabolism
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Protein Interaction Mapping / methods
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Tissue Distribution / genetics
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Tissue Distribution / immunology
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Transcription Factors / chemistry
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Transcription Factors / physiology*
Substances
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Antigens
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Transcription Factors