The mechanism of tissue-restricted antigen gene expression by AIRE

J Immunol. 2013 Mar 15;190(6):2479-82. doi: 10.4049/jimmunol.1203210.

Abstract

The autoimmune regulator is a critical transcription factor for generating central tolerance in the thymus. Recent studies have revealed how the autoimmune regulator targets many otherwise tissue-restricted Ag genes to enable negative selection of autoreactive T cells.

Publication types

  • Review

MeSH terms

  • AIRE Protein
  • Amino Acid Motifs / genetics
  • Animals
  • Antigens / biosynthesis
  • Antigens / chemistry
  • Antigens / genetics*
  • Conserved Sequence / immunology
  • Gene Expression Regulation / immunology*
  • Humans
  • Immune Tolerance / genetics
  • Mice
  • Mice, Knockout
  • Polyendocrinopathies, Autoimmune / genetics
  • Polyendocrinopathies, Autoimmune / immunology
  • Polyendocrinopathies, Autoimmune / metabolism
  • Protein Interaction Mapping / methods
  • Tissue Distribution / genetics
  • Tissue Distribution / immunology
  • Transcription Factors / chemistry
  • Transcription Factors / physiology*

Substances

  • Antigens
  • Transcription Factors