In vitro tumor cytotoxic activities of extracts from three Liriodendron plants

Pak J Pharm Sci. 2013 Mar;26(2):233-7.

Abstract

The extracts prepared from Liriodendron tulipifera Linn., L. chinense (Hemsl.) Sarg., and their hybrid L. chinense x L. tulipifera, were investigated for their cytotoxic abilities in vitro against five human cancer cell lines: MDA-MB-231 and MCF-7 breast cancer cells, SGC-7901 gastric cancer cells, HuH-7 hepatocarcinoma cells, and HCT-15 colon carcinoma cells, and then measured their phenols and alkaloids contents. Of these plant extracts, some of them, especially the lower polar extracts from barks, exhibited potent cytotoxic effects on five tested tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / analysis
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Antineoplastic Agents, Phytogenic / analysis
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Humans
  • Inhibitory Concentration 50
  • Liriodendron / chemistry*
  • MCF-7 Cells
  • Neoplasms / pathology*
  • Phenols / analysis
  • Phenols / isolation & purification
  • Phenols / pharmacology*
  • Plant Bark
  • Plant Extracts / analysis
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Plants, Medicinal

Substances

  • Alkaloids
  • Antineoplastic Agents, Phytogenic
  • Phenols
  • Plant Extracts