Abstract
Polarized growth of the yeast Saccharomyces cerevisiae depends on different biological processes and requires several signaling pathways. Signaling is mediated through a set of proteins, which include Rho3p and Rho4p GTPases. Although these two proteins are involved in the control of distinct aspects of polarized growth in yeast, they have a common regulator: the Rgd1 RhoGAP protein. Here we demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and we observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Aurora Kinases
-
Cytokinesis
-
GTPase-Activating Proteins / chemistry
-
GTPase-Activating Proteins / genetics
-
GTPase-Activating Proteins / metabolism*
-
Genes, Fungal
-
Intracellular Signaling Peptides and Proteins / antagonists & inhibitors
-
Intracellular Signaling Peptides and Proteins / genetics
-
Intracellular Signaling Peptides and Proteins / metabolism*
-
Mutation
-
Phosphorylation
-
Protein Processing, Post-Translational
-
Protein Serine-Threonine Kinases / antagonists & inhibitors
-
Protein Serine-Threonine Kinases / genetics
-
Protein Serine-Threonine Kinases / metabolism*
-
Recombinant Fusion Proteins / chemistry
-
Recombinant Fusion Proteins / genetics
-
Recombinant Fusion Proteins / metabolism
-
Saccharomyces cerevisiae / cytology
-
Saccharomyces cerevisiae / genetics
-
Saccharomyces cerevisiae / growth & development
-
Saccharomyces cerevisiae / metabolism*
-
Saccharomyces cerevisiae Proteins / antagonists & inhibitors
-
Saccharomyces cerevisiae Proteins / chemistry
-
Saccharomyces cerevisiae Proteins / genetics
-
Saccharomyces cerevisiae Proteins / metabolism*
-
Signal Transduction
Substances
-
GTPase-Activating Proteins
-
Intracellular Signaling Peptides and Proteins
-
RGD1 protein, S cerevisiae
-
Recombinant Fusion Proteins
-
Saccharomyces cerevisiae Proteins
-
Aurora Kinases
-
IPL1 protein, S cerevisiae
-
Protein Serine-Threonine Kinases