Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates

Chung-Kyu Ryu; Ae Li Song; Jung An Hong

doi:10.1016/j.bmcl.2013.01.130

Synthesis and antifungal evaluation of 7-arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2065-8. doi: 10.1016/j.bmcl.2013.01.130. Epub 2013 Feb 13.

Authors

Chung-Kyu Ryu¹, Ae Li Song, Jung An Hong

Affiliation

¹ College of Pharmacy & Division of Life and Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-ku, Seoul 120-750, Republic of Korea. ckryu@ewha.ac.kr

PMID: 23453842
DOI: 10.1016/j.bmcl.2013.01.130

Abstract

7-Arylamino-5,8-dioxo-5,8-dihydroisoquinoline-4-carboxylates were synthesized and tested for in vitro antifungal activity against two pathogenic strains of fungi. Most of tested compounds showed good antifungal activity. The results suggest that those 5,8-dioxo-5,8-dihydroisoquinolines would be potent antifungal agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Aspergillus / drug effects*
Candida / classification
Candida / drug effects*
Carboxylic Acids / chemical synthesis
Carboxylic Acids / chemistry
Carboxylic Acids / pharmacology*
Cryptococcus neoformans / drug effects*
Dose-Response Relationship, Drug
Isoquinolines / chemical synthesis
Isoquinolines / chemistry
Isoquinolines / pharmacology*
Microbial Sensitivity Tests
Molecular Structure
Structure-Activity Relationship

Substances

Antifungal Agents
Carboxylic Acids
Isoquinolines