Adenoid cystic carcinoma of the head and neck: clinicopathologic analysis of 218 cases in a Chinese population

Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):368-75. doi: 10.1016/j.oooo.2012.11.018.

Abstract

Objective: The aim of this study was to analyze the clinicopathologic characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck (ACCHN).

Study design: This was a retrospective study of 218 patients with ACCHN.

Results: The cohort included 110 men and 108 women; the parotid and the palate were the most common site of involvement. Of 203 patients with follow-up information (range 2-132 months), 57 had died of the tumor. Distant metastasis (DM) and local recurrence (LR) were documented in 83 (40.9%) and 34 (16.7%) patients, respectively. Cox regression analysis indicated that a solid pattern was a marker for LR and that positive margins and older age were risk factors for DM. Histologic pattern, T stage, N stage, LR, DM, and patient age contributed to the prediction of disease-specific survival.

Conclusions: A solid pattern, metastasis, LR, and older age are the most important factors for predicting poor prognosis in Chinese patients with ACCHN.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Carcinoma, Adenoid Cystic / pathology*
  • Carcinoma, Adenoid Cystic / secondary
  • Cause of Death
  • China
  • Cohort Studies
  • Disease-Free Survival
  • Female
  • Follow-Up Studies
  • Head and Neck Neoplasms / pathology*
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / pathology
  • Neoadjuvant Therapy
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Staging
  • Palatal Neoplasms / pathology
  • Parotid Neoplasms / pathology
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • Tongue Neoplasms / pathology
  • Young Adult