The first reported case of rabbit hemorrhagic disease in Canada

Can Vet J. 2012 Sep;53(9):998-1002.

Abstract

In March 2011, rabbit hemorrhagic disease (RHD) was suspected in a 1-year-old male neutered lop-eared rabbit that had acute onset liver failure. Gross pathology, histopathology, immunohistochemistry, partial nucleic acid sequencing and phylogenetic analysis of the major capsid protein (VP60) and animal inoculation studies all supported this diagnosis making it the first confirmed case of RHD in Canada.

In March 2011, rabbit hemorrhagic disease (RHD) was suspected in a 1-year-old male neutered lop-eared rabbit that had acute onset liver failure. Gross pathology, histopathology, immunohistochemistry, partial nucleic acid sequencing and phylogenetic analysis of the major capsid protein (VP60) and animal inoculation studies all supported this diagnosis making it the first confirmed case of RHD in Canada.

RésuméLe premier cas signalé de maladie hémorragique du lapin au Canada. En mars 2011, la maladie hémorragique du lapin (MHL) a été suspectée chez un lapin bélier mâle castré âgé de 1 an qui a présenté l’apparition soudaine d’une insuffisance hépatique. La pathologie macroscopique, l’histopathologie, l’immunohistochimie, le séquençage partiel de l’acide nucléique et l’analyse phylogénétique de la principale protéine de la capside (VP60) et des études d’inoculation animale ont confirmé d’emblée ce diagnostic, ce qui en fait le premier cas confirmé de MHL au Canada.(Traduit par Isabelle Vallières).

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Base Sequence
  • Caliciviridae Infections / diagnosis
  • Caliciviridae Infections / epidemiology
  • Caliciviridae Infections / veterinary*
  • Caliciviridae Infections / virology
  • Canada / epidemiology
  • Capsid Proteins / genetics
  • Capsid Proteins / metabolism
  • Diagnosis, Differential
  • Fatal Outcome
  • Hemorrhagic Disease Virus, Rabbit / genetics
  • Hemorrhagic Disease Virus, Rabbit / isolation & purification*
  • Male
  • Rabbits

Substances

  • Capsid Proteins