Selective ruthenium-catalyzed transfer hydrogenations of nitriles to amines with 2-butanol

Chemistry. 2013 Apr 2;19(14):4437-40. doi: 10.1002/chem.201204633. Epub 2013 Feb 28.

Abstract

Transfer your hydrogen: Fast and general transfer hydrogenation of nitriles to form primary amines is possible with a homogeneous Ru/1,4-bis(diphenylphosphino)butane (DPPB) catalyst (see scheme). The use of 2-butanol as the hydrogen-transfer reagent is essential for the selective reduction of aromatic, heteroaromatic, and aliphatic nitriles with this system.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Amines / chemical synthesis*
  • Amines / chemistry
  • Butanols / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Hydrogen
  • Hydrogenation
  • Nitriles / chemistry*
  • Ruthenium / chemistry*

Substances

  • Alkynes
  • Amines
  • Butanols
  • Nitriles
  • 2-butanol
  • Ruthenium
  • Hydrogen