Continuous-flow synthesis of 1-substituted benzotriazoles from chloronitrobenzenes and amines in a C-N bond formation/hydrogenation/diazotization/cyclization sequence

Angew Chem Int Ed Engl. 2013 Apr 8;52(15):4247-50. doi: 10.1002/anie.201300615. Epub 2013 Mar 1.

Authors

Mao Chen¹, Stephen L Buchwald

Affiliation

¹ Department of Chemistry, Room 18-490, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

PMID: 23450692
DOI: 10.1002/anie.201300615

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines / chemistry*
Cyclization
Hydrogenation
Molecular Structure
Nitrobenzenes / chemistry*
Triazoles / chemical synthesis*
Triazoles / chemistry

Substances

Amines
Nitrobenzenes
Triazoles
benzotriazole
4-chloronitrobenzene