Pioneering barren land: mitotic bookmarking by transcription factors

Alvaro Rada-Iglesias

doi:10.1016/j.devcel.2013.02.005

Pioneering barren land: mitotic bookmarking by transcription factors

Dev Cell. 2013 Feb 25;24(4):342-4. doi: 10.1016/j.devcel.2013.02.005.

Author

Alvaro Rada-Iglesias¹

Affiliation

¹ Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305, USA. alvaro.rada-iglesias@uni-koeln.de

PMID: 23449470
DOI: 10.1016/j.devcel.2013.02.005

Abstract

Genome condensation during mitosis presents a chromatin landscape largely inaccessible to RNA polymerase II and most transcription factors. Caravaca et al. (2013) now report in Genes and Development that the pioneer transcription factor FOXA1 is retained at mitotic chromosomes, bookmarking the genome to enable gene expression reestablishment upon mitotic exit.

Publication types

Comment