Synthesis and biological activity of new donepezil-hydrazinonicotinamide hybrids

Drug Res (Stuttg). 2013 Mar;63(3):137-44. doi: 10.1055/s-0033-1333735. Epub 2013 Feb 14.

Abstract

Currently available treatment used in Alzheimer's disease is based on acetylcholinesterase inhibitors, e. g. donepezil, tacrine, galantamine, and rivastigmine. In the present study some derivatives of donepezil were synthesized, and their potential anticholinesterase properties were investigated using the colorimetric Ellman's method. These compounds were synthesized by condensation between indanone derivatives and the hydrazine nicotinated moiety (Hynic). For received derivatives, the selectivity and the IC50 values for acetylcholinesterase and butyrylcholinesterase were calculated. All the tested compounds exhibited lower affinity for AChE than donepezil and higher affinity for BChE than donepezil. Compound 33 showed the most selectivity for AChE among the obtained indanone derivatives.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / drug therapy
  • Alzheimer Disease / physiopathology
  • Butyrylcholinesterase / drug effects
  • Butyrylcholinesterase / metabolism
  • Cholinesterase Inhibitors / chemical synthesis
  • Cholinesterase Inhibitors / chemistry
  • Cholinesterase Inhibitors / pharmacology*
  • Colorimetry
  • Donepezil
  • Indans / chemical synthesis
  • Indans / chemistry
  • Indans / pharmacology*
  • Inhibitory Concentration 50
  • Niacinamide / analogs & derivatives*
  • Niacinamide / chemical synthesis
  • Niacinamide / chemistry
  • Niacinamide / pharmacology
  • Piperidines / chemical synthesis
  • Piperidines / chemistry
  • Piperidines / pharmacology*

Substances

  • Cholinesterase Inhibitors
  • Indans
  • Piperidines
  • hydrazinonictinamide
  • Niacinamide
  • Donepezil
  • Butyrylcholinesterase