Abstract
Lactococcus lactis is modified to express a fibronectin fragment (FNIII₇₋₁₀) as a membrane protein. This interphase, based on a living system, can be further exploited to provide spatio-temporal factors to direct cell function at the material interface. This approach establishes a new paradigm in biomaterial surface functionalization for biomedical applications.
Keywords:
bacteria; cell adhesion; fibronectin; integrin; interface.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Adhesion
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Cell Line
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Cell Survival
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Fibroblasts / cytology
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Fibroblasts / metabolism
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Fibronectins / chemistry
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Fibronectins / genetics
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Fibronectins / metabolism*
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Focal Adhesion Protein-Tyrosine Kinases / metabolism
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Green Fluorescent Proteins / genetics
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Green Fluorescent Proteins / metabolism
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Humans
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Lactococcus lactis / metabolism*
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Mice
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Microscopy, Confocal
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Protein Binding
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Recombinant Fusion Proteins / chemistry
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Signal Transduction
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Surface Properties
Substances
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Fibronectins
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Recombinant Fusion Proteins
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Green Fluorescent Proteins
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Focal Adhesion Protein-Tyrosine Kinases