Dual treatment of hemichorea-hemiballismus syndrome with tetrabenazine and chemodenervation

Tremor Other Hyperkinet Mov (N Y). 2012:2:tre-02-113-791-3. doi: 10.7916/D86Q1VZD. Epub 2012 Oct 19.

Abstract

Background: Hemichorea-hemiballismus involves unilateral involuntary flailing movements and random jerking movements involving proximal or distal muscles. We describe a case of hemichorea-hemiballismus with dystonia after stroke. Treatment with tetrabenazine and chemodenervation produced beneficial responses. Effective treatment of both hemichorea-hemiballismus and dystonia due to stroke has not been reported.

Case report: A 65-year-old male developed left hemichorea-hemiballismus and dystonia after a right hemisphere stroke. He underwent initial treatment with neuroleptics and anticonvulsants without improvement. Subsequent treatment with tetrabenazine improved the hemichorea-hemiballismus and chemodenervation reduced the dystonia.

Discussion: Hemichorea-hemiballismus associated with dystonia can be improved with both tetrabenazine and chemodenervation.

Keywords: Hemichorea–hemiballismus; chemodenervation; dystonia; hyperkinetic movements; onabotulinumtoxinA; tetrabenazine.