Ultra-small NLC for improved dermal delivery of coenyzme Q10

Int J Pharm. 2013 Apr 15;447(1-2):213-7. doi: 10.1016/j.ijpharm.2013.02.037. Epub 2013 Feb 21.

Abstract

Coenzyme Q10 (CoQ10) acts as an antioxidant in the skin and is frequently contained in anti-aging products. In previous studies, it could be shown that nano-structured lipid carriers (NLC) with a size of about 230 nm are beneficial for the dermal delivery of CoQ10. They increased Q10 skin penetration when compared to equally sized nanoemulsion. In this study, ultra-small NLC were prepared with even smaller mean particles sizes of around 80 nm. The influence of this decrease of particle size was investigated in terms of skin permeation and penetration as well as physicochemical stability of the NLC. Improved dermal delivery of CoQ10 by ultra-small NLC could be achieved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Antioxidants / administration & dosage*
  • Antioxidants / chemistry
  • Drug Carriers / administration & dosage*
  • Drug Carriers / chemistry
  • Lipids / chemistry
  • Nanoparticles / administration & dosage*
  • Nanoparticles / chemistry
  • Particle Size
  • Skin / metabolism
  • Skin Absorption
  • Swine
  • Ubiquinone / administration & dosage
  • Ubiquinone / analogs & derivatives*
  • Ubiquinone / chemistry

Substances

  • Antioxidants
  • Drug Carriers
  • Lipids
  • Ubiquinone
  • coenzyme Q10