Abstract
Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Cycle / drug effects
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Chalcones / chemistry
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Chalcones / isolation & purification
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Chalcones / pharmacology*
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Drug Screening Assays, Antitumor
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Female
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Flavonoids / chemistry
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Flavonoids / isolation & purification
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Flavonoids / pharmacology*
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Humans
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Molecular Structure
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Structure-Activity Relationship
Substances
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2'-hydroxy-3,4,3',4',6'-pentamethoxychalcone
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Chalcones
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Coumarins
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Flavonoids
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3-hydroxyflavone