Proteostasis modulators with discriminating taste

Ville O Paavilainen; Jack Taunton

doi:10.1016/j.chembiol.2013.02.002

Proteostasis modulators with discriminating taste

Chem Biol. 2013 Feb 21;20(2):144-5. doi: 10.1016/j.chembiol.2013.02.002.

Authors

Ville O Paavilainen¹, Jack Taunton

Affiliation

¹ Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA.

Abstract

Small molecules that perturb protein homeostasis are used as cancer therapeutics and as antibiotics to treat bacterial infections. In a recent issue of Cell, Kannan and colleagues describe an intriguing mechanism that enables ribosome-targeted macrolides to selectively remodel the bacterial proteome. This finding suggests the exciting possibility of targeting additional proteostasis regulators in a substrate-selective manner.

Publication types

Comment

Grants and funding

R01 GM081644/GM/NIGMS NIH HHS/United States