In search of the missing ligands for TetR family regulators

Christophe Corre

doi:10.1016/j.chembiol.2013.02.005

In search of the missing ligands for TetR family regulators

Chem Biol. 2013 Feb 21;20(2):140-2. doi: 10.1016/j.chembiol.2013.02.005.

Author

Christophe Corre¹

Affiliation

¹ Department of Chemistry, University of Warwick, Coventry CV4 7AL, UK. c.corre@warwick.ac.uk

PMID: 23438741
DOI: 10.1016/j.chembiol.2013.02.005

Abstract

The TetR family of microbial transcription factors directly control the expression of a diverse range of genes in bacteria by sensing specific ligands. In this issue of Chemistry & and Biology, Cuthbertson and colleagues used phylogenomics to guide the identification of TetR-like protein cognate ligands and revealed a novel inducible antibiotic resistance mechanism.

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