Lipocryolysis is considered as an effective, well-tolerated non-invasive procedure to reduce local adiposities. However there is little information about its mechanism of action by the procedure. It is proposed that lipid phase transition or crystallization may be an unleashed apoptotic stimulus. Yet, the post-lipocryolysis apoptosis is not easily confirmed, least of all is its correlation with crystallization. In this study adipocytes from rat fat tissue were exposed to a lipocryolysis-session-like stimulus. Lipid changes were observed in all test sample.