Absence of Pneumocystis dihydropteroate synthase mutants in Brittany, France

Diagn Microbiol Infect Dis. 2013 May;76(1):113-5. doi: 10.1016/j.diagmicrobio.2013.01.018. Epub 2013 Feb 20.

Abstract

Archival Pneumocystis jirovecii specimens from 84 patients monitored at Rennes University Hospital (Rennes, France) were assayed at the dihydropteroate synthase (DHPS) locus. No patient was infected with mutants. The results provide additional data showing that P. jirovecii infections involving DHPS mutants do not represent a public health issue in Brittany, western France.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Bronchoalveolar Lavage
  • DNA, Fungal / genetics
  • Dihydropteroate Synthase / genetics*
  • Female
  • France / epidemiology
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Pneumocystis carinii / drug effects
  • Pneumocystis carinii / genetics*
  • Pneumocystis carinii / isolation & purification
  • Pneumonia, Pneumocystis / drug therapy
  • Pneumonia, Pneumocystis / epidemiology
  • Pneumonia, Pneumocystis / microbiology
  • Specimen Handling
  • Sulfonamides / therapeutic use

Substances

  • DNA, Fungal
  • Sulfonamides
  • Dihydropteroate Synthase