Prevalence of plasmid-mediated quinolone resistance determinants in Enterobacteriaceae strains isolated in North-East Italy

J Chemother. 2013 Feb;25(1):36-40. doi: 10.1179/1120009X12Z.00000000078.

Abstract

We investigated the prevalence of plasmid-mediated quinolone resistance genes in 756 clinical isolates of Enterobacteriaceae originating from Microbiology Diagnostic Laboratories of North-East Italy. Five point zero two percent of isolates carried a qnr determinant while the aac(6')-Ib-cr determinant was detected in 9·25% of isolates. We also investigated the association between the plasmid-mediated quinolone resistance and the beta-lactamase genes, and characterized the plasmids carrying these determinants of resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Drug Resistance, Bacterial
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / drug therapy
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli Proteins / genetics
  • Fluoroquinolones / pharmacology*
  • Humans
  • Italy
  • Microbial Sensitivity Tests
  • Plasmids / genetics*
  • Prevalence
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Escherichia coli Proteins
  • Fluoroquinolones
  • Qnr protein, E coli
  • beta-Lactamases