Abstract
In addition to their participation in metabolic processes and control of programmed cell death, the role of mitochondria as a fundamental hub for innate anti-viral immunity is now emerging. The participation of the mitochondrial antiviral signaling protein (MAVS) as a central regulator of a complex signaling cascade, which results in the induction of antiviral and inflammatory responses has been described. A patent based on this role of MAVS is highlighted in this review.
MeSH terms
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Adaptor Proteins, Signal Transducing / metabolism*
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Animals
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Antiviral Agents / pharmacology*
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Drug Design
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Humans
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Immunity, Innate / drug effects
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Mitochondria / drug effects*
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Mitochondria / immunology
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Mitochondria / metabolism
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Mitochondria / virology
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Patents as Topic
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Signal Transduction / drug effects
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Virus Diseases / drug therapy*
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Virus Diseases / immunology
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Virus Diseases / metabolism
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Virus Diseases / virology
Substances
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Adaptor Proteins, Signal Transducing
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Antiviral Agents
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MAVS protein, human