Abstract
A fully convergent one-pot two-step synthesis of different chiral 1,2,3-triazole-derived diols in high yields and excellent enantio- and diastereoselectivities has been achieved under very mild conditions in aqueous medium by combining a single alcohol dehydrogenase (ADH) with a Cu-catalysed 'click' reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alcohol Dehydrogenase / chemistry
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Alcohol Dehydrogenase / metabolism*
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Alcohols / chemical synthesis*
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Alcohols / chemistry
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Alcohols / metabolism*
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Catalysis
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Click Chemistry
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Copper / chemistry*
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Cyclization
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Molecular Structure
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Stereoisomerism
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Triazoles / chemical synthesis*
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Triazoles / chemistry
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Triazoles / metabolism*
Substances
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Alcohols
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Triazoles
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Copper
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Alcohol Dehydrogenase