Propofol-interrupted tinnitus later suppressed by amantadine: a case-report

J Clin Pharmacol. 2013 Mar;53(3):356-8. doi: 10.1002/jcph.6. Epub 2013 Feb 20.

Abstract

Tinnitus is a frequent condition without consistently effective remediation. Mr V. was a 64 year old man with Behcet's disease, a generalized systemic relapsing vasculitis. Tinnitus appeared in 1998 and he had been both aware and distressed by his tinnitus 80% of his awake time. After his last colonoscopic examination, he mentioned a transient interruption of his tinnitus. Mr V. only received propofol, an anesthesic drug that selectively down-regulates glutamatergic synaptic transmission. Amantadine, another glutamate antagonist, was later prescribed and durably suppressed tinnitus. Systematically inquiry about post-anesthesia effects on tinnitus may help decide if amantadine may be tried on an individual basis.

Publication types

  • Case Reports

MeSH terms

  • Amantadine / therapeutic use*
  • Anesthetics, Intravenous / therapeutic use*
  • Behcet Syndrome
  • Excitatory Amino Acid Antagonists / therapeutic use*
  • Humans
  • Male
  • Middle Aged
  • Propofol / therapeutic use*
  • Tinnitus / drug therapy*

Substances

  • Anesthetics, Intravenous
  • Excitatory Amino Acid Antagonists
  • Amantadine
  • Propofol