Kidney regeneration and repair after transplantation

Curr Opin Organ Transplant. 2013 Apr;18(2):191-6. doi: 10.1097/MOT.0b013e32835f0771.

Abstract

Purpose of review: To briefly show which are the mechanisms and cell types involved in kidney regeneration and describe some of the therapies currently under study in regenerative medicine for kidney transplantation.

Recent findings: The kidney contains cell progenitors that under specific circumstances have the ability to regenerate specific structures. Apart from the knowledge gained in the self-regenerative properties of the kidney, new concepts in regenerative medicine such as organ engineering and the use of mesenchymal stem cell-based therapies are currently the focus of attention in the field.

Summary: Overall, kidney regeneration is a reality and the knowledge on how to control it will be one of the main scopes in the present and future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Kidney / physiology*
  • Kidney Transplantation*
  • Mesenchymal Stem Cell Transplantation
  • Regeneration / physiology*
  • Regenerative Medicine / methods*
  • Stem Cell Transplantation / trends
  • Tissue Engineering / methods*