Feathers have many advantages that make them an excellent nondestructive tool for monitoring polyhalogenated compounds (PHCs). This paper proposes a review on the PHCs in feathers and factors influencing the pollutant load. Special attention has given to external contamination and the main analytical methods used to detect these compounds in feathers. Some authors have found strong and significant correlations between the concentrations of PHCs in feathers and internal tissues, providing positive expectations for their future use in the field of ecotoxicology. However, changes in diet, time elapsed between the previous molt period and sampling, sample size, and/or external contamination have been suggested as possible causes to explain the lack of correlations reported in some studies. Further studies with newly grown feathers and blood samples would be required in order to clarify this issue. Although atmospheric deposition has been reported as cause of external contamination, preening oil seems to be the most relevant factor contributing to this process. Unfortunately, washing techniques tested to date are not able to effectively remove the surface contamination from barbs and shafts, and therefore, it is necessary to develop methods able to discriminate between internal and external contamination. Finally, in this review, deposition rate is proposed as a measurement unit, as this allows comparisons between different parts of the same feather, as well as between different feathers.