Aerobic oxidative Heck/dehydrogenation reactions of cyclohexenones: efficient access to meta-substituted phenols

Angew Chem Int Ed Engl. 2013 Mar 25;52(13):3672-5. doi: 10.1002/anie.201209457. Epub 2013 Feb 19.

Abstract

A new dicationic PdII catalyst, employing a 6,6'-dimethylbipyridine ligand, has been identified that is capable of promoting both aerobic oxidative Heck coupling and dehydrogenation reactions of cyclohexenones. These reactions may be combined in a one-pot sequence to enable the straightforward synthesis of meta-substituted phenols.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Coordination Complexes / chemistry
  • Cyclohexenes / chemistry*
  • Isomerism
  • Oxidation-Reduction
  • Palladium / chemistry
  • Phenols / chemistry*

Substances

  • Coordination Complexes
  • Cyclohexenes
  • Phenols
  • cyclohexene
  • Palladium