Circulating immune complexes (CIC) rises in response to immunogens appearing in human body. An increasing of the CIC concentration is observed in allergies as well as many others diseases. As a result of inflammatory process localized within intracellular space heat shock proteins (HSP) may occur. The aim of work was the CIC levels estimation as well as CIC HSP-70 presence analysis in serum of smoking and non-smoking allergy sufferers. Serum from 12 smoking and 15 non-smoking patients were examined. Serum from 34 healthy persons constituted the control group. The level of CIC was established by Haskowa precipitation method. The identification of HSP-70 antigen within CIC was determined by Dot blot method. We discovered increased CIC levels in serum from smoking allergy sufferers in comparison with non-smokers. The highest percentage of HSP-70 presence within CIC was observed in smoking allergy sufferers.