Cell to extracellular matrix interactions and their reciprocal nature in cancer

Marianne van Dijk; Sara A Göransson; Staffan Strömblad

doi:10.1016/j.yexcr.2013.02.006

Cell to extracellular matrix interactions and their reciprocal nature in cancer

Exp Cell Res. 2013 Jul 1;319(11):1663-70. doi: 10.1016/j.yexcr.2013.02.006. Epub 2013 Feb 16.

Authors

Marianne van Dijk¹, Sara A Göransson², Staffan Strömblad³

Affiliations

¹ Karolinska Institutet, Department of Biosciences and Nutrition, Huddinge SE-141 83, Sweden. Electronic address: marianne.van.dijk@ki.se.
² Karolinska Institutet, Department of Biosciences and Nutrition, Huddinge SE-141 83, Sweden.
³ Karolinska Institutet, Department of Biosciences and Nutrition, Huddinge SE-141 83, Sweden. Electronic address: staffan.stromblad@ki.se.

PMID: 23419246
DOI: 10.1016/j.yexcr.2013.02.006

Abstract

Interactions between the cell and the extracellular matrix (ECM) are critical in controlling the fate and behaviour of cancer cells. Alterations in either the ECM or in cellular events affect this interaction. In this mini-review we give an overview of the role of cell-ECM interactions in cancer, with a particular focus on the reciprocal nature of the cell-ECM interactions and how this contributes to cancer progression.

Keywords: Contraction; ECM; Integrin; Remodelling; Stiffness; Tension.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Communication*
Cell Physiological Phenomena*
Extracellular Matrix / pathology*
Humans
Neoplasms / pathology*