Maternal and pregnancy related predictors of cardiometabolic traits in newborns

PLoS One. 2013;8(2):e55815. doi: 10.1371/journal.pone.0055815. Epub 2013 Feb 13.

Abstract

Background: The influence of multiple maternal and pregnancy characteristics on offspring cardiometabolic traits at birth is not well understood and was evaluated in this study.

Methods and findings: The Family Atherosclerosis Monitoring In earLY life (FAMILY) Study prospectively evaluated 11 cardiometabolic traits in 901 babies born to 857 mothers. The influence of maternal age, health (pre-pregnancy weight, blood pressure, glycemic status, lipids), health behaviors (diet, activity, smoking) and pregnancy characteristics (gestational age at birth, gestational weight gain and placental-fetal ratio) were examined. Greater gestational age influenced multiple newborn cardiometabolic traits including cord blood lipids, glucose and insulin, body fat and blood pressure. In a subset of 442 singleton mother/infant pairs, principal component analysis grouped 11 newborn cardiometabolic traits into 5 components (anthropometry/insulin, 2 lipid components, blood pressure and glycemia), accounting for 74% of the variance of the 11 outcome variables. Determinants of these components, corrected for sex and gestational age, were examined. Baby anthropometry/insulin was independently predicted by higher maternal pre-pregnancy weight (standardized estimate 0.30) and gestational weight gain (0.30; both p<0.0001) and was inversely related to smoking during pregnancy (-0.144; p = 0.01) and maternal polyunsaturated to saturated fat intake (-0.135;p = 0.01). Component 2 (HDL-C/Apo Apolipoprotein1) was inversely associated with maternal age. Component 3 (blood pressure) was not clustered with any other newborn cardiometabolic trait and no associations with maternal pregnancy characteristics were identified. Component 4 (triglycerides) was positively associated with maternal hypertension and triglycerides, and inversely associated with maternal HDL and age. Component 5 (glycemia) was inversely associated with placental/fetal ratio (-0.141; p = 0.005). LDL-C was a bridging variable between the lipid factors and glycemia.

Conclusions: Maternal health, health behaviours and placenta to fetal weight ratio are associated with newborn cardiometabolic traits over and above gestational age. Future investigations are needed to determine if these factors remain important determinants of cardiometabolic health throughout childhood.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Birth Weight / physiology*
  • Blood Glucose / metabolism
  • Blood Pressure / physiology*
  • Body Weight
  • Female
  • Fetal Blood / metabolism*
  • Gestational Age
  • Health Behavior
  • Humans
  • Infant, Newborn
  • Insulin / blood
  • Lipids / blood
  • Male
  • Maternal Age
  • Pregnancy
  • Prospective Studies

Substances

  • Blood Glucose
  • Insulin
  • Lipids

Grants and funding

This study was funded by the Canadian Institutes of Health Research, Heart and Stroke Foundation of Ontario and the Population Health Research Institute. S.S.A. holds a Canada Research Chair in Ethnicity and Cardiovascular Disease, and the Michael DeGroote Heart and Stroke Foundation Chair in Population Health. S.D.M. is supported by a Canadian Institutes of Health Research New Investigator Salary Award. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.