Single nucleotide polymorphisms rs2120131, rs4935047, and rs7095891 in the MBL2 gene show no association with susceptibility to chronic hepatitis B in a Chinese Han population

Tian-Chen Zhang; Wei Liu; Xiao-Qing Liu; Fa-Ming Pan; Yu-Feng Gao; Fang Yan; Xu Li

doi:10.1002/jmv.23514

Single nucleotide polymorphisms rs2120131, rs4935047, and rs7095891 in the MBL2 gene show no association with susceptibility to chronic hepatitis B in a Chinese Han population

J Med Virol. 2013 Apr;85(4):602-7. doi: 10.1002/jmv.23514.

Authors

Tian-Chen Zhang¹, Wei Liu, Xiao-Qing Liu, Fa-Ming Pan, Yu-Feng Gao, Fang Yan, Xu Li

Affiliation

¹ Jiangxi Center for Disease Control and Prevention, 555 Beijing East Road, Nanchang, Jiangxi 330000, China.

PMID: 23417614
DOI: 10.1002/jmv.23514

Abstract

Thus far, many studies have evaluated the correlation between MBL2 gene polymorphisms and hepatitis B infection. Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between MBL2 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls. There was no significant correlation between rs2120131, rs4935047, and rs7095891 and chronic HBV infection. This suggested that the new SNPs within MBL2 were not associated with susceptibility to chronic hepatitis B in a Chinese Han population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
China
Female
Genetic Predisposition to Disease*
Hepatitis B, Chronic / genetics*
Humans
Male
Mannose-Binding Lectin / genetics*
Polymorphism, Single Nucleotide*

Substances

MBL2 protein, human
Mannose-Binding Lectin