Abstract
Three lichen extracts and ten lichenic compounds have been screened for their photoprotective activities. The determination of their Sun Protection Factor (SPF) and Protection Factor-UVA (PF-UVA) values was done in vitro. Among them, a Lasallia pustulata extract and gyrophoric acid exhibited SPF values over 5, which is better than Homosalate (SPF≈4). Their photoprotective properties are only slightly modified after a 2-hours period of irradiation. Salazinic acid and L. pustulata presented characteristics of a UVA booster like the butyl-methoxydibenzoylmethane (Avobenzone) (PF-UVA≈2 vs. 2.8 for Avobenzone). Salazinic acid was a better anion superoxide scavenger than ascorbic acid and none of them exhibited a photosensitizing cytotoxicity by exposing them on HaCaT cells to UVA radiations (photo-irritancy factor PIF<5).
Copyright © 2013 Elsevier B.V. All rights reserved.
MeSH terms
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Antioxidants / isolation & purification
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Antioxidants / metabolism
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Antioxidants / pharmacology
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Antioxidants / toxicity
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Ascomycota / chemistry
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Ascomycota / metabolism
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Benzoates / isolation & purification
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Benzoates / metabolism
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Benzoates / pharmacology
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Benzoates / toxicity
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Benzofurans / isolation & purification
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Benzofurans / metabolism
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Benzofurans / pharmacology
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Benzofurans / toxicity
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Cell Line
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Fumarates / isolation & purification
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Fumarates / metabolism
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Fumarates / pharmacology
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Fumarates / toxicity
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Humans
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Lactones / isolation & purification
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Lactones / metabolism
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Lactones / pharmacology
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Lactones / toxicity
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Salicylates / isolation & purification
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Salicylates / metabolism
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Salicylates / pharmacology
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Salicylates / toxicity
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Sun Protection Factor / methods*
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Ultraviolet Rays*
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Usnea / chemistry*
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Usnea / metabolism*
Substances
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Antioxidants
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Benzoates
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Benzofurans
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Fumarates
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Lactones
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Salicylates
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salazinic acid
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usnic acid
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fumarprotocetraric acid
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gyrophoric acid