Uncertainty modeling for ontology-based mammography annotation with intelligent BI-RADS scoring

Comput Biol Med. 2013 May;43(4):301-11. doi: 10.1016/j.compbiomed.2013.01.001. Epub 2013 Feb 14.

Abstract

This paper presents an ontology-based annotation system and BI-RADS (Breast Imaging Reporting and Data System) score reasoning with Semantic Web technologies in mammography. The annotation system is based on the Mammography Annotation Ontology (MAO) where the BI-RADS score reasoning works. However, ontologies are based on crisp logic and they cannot handle uncertainty. Consequently, we propose a Bayesian-based approach to model uncertainty in mammography ontology and make reasoning possible using BI-RADS scores with SQWRL (Semantic Query-enhanced Web Rule Language). First, we give general information about our system and present details of mammography annotation ontology, its main concepts and relationships. Then, we express uncertainty in mammography and present approaches to handle uncertainty issues. System is evaluated with a manually annotated dataset DEMS (Dokuz Eylul University Mammography Set) and DDSM (Digital Database for Screening Mammography). We give the result of experimentations in terms of accuracy, sensitivity, precision and uncertainty level measures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Bayes Theorem
  • Breast / pathology*
  • Breast Neoplasms / diagnosis*
  • Calcinosis / pathology
  • Computer Simulation
  • Diagnosis, Computer-Assisted / methods*
  • Female
  • Humans
  • Mammography / methods*
  • Models, Statistical
  • Programming Languages
  • Uncertainty
  • User-Computer Interface