Two novel phenethylamine alkaloids from streptomyces sp. YIM10049

Nat Prod Commun. 2012 Dec;7(12):1579-80.

Abstract

Two novel phenethylamine alkaloids were isolated from Streptomyces sp. YIM 10049. On the basis of spectral data, their structures were determined as (S)-N-(cu-phenylethyl)-2 -hydroxyl-acrylimine (1) and (S)-N-nitroso-1-amino-p-hydroxy phenylethanol (2). Three known compounds, indole-3-carboxylic acid (3), cyclo(L-Ala-L-Tyr)(4), and bis(2-ethylhexyl) phthalate (5), were also isolated and characterized. Compound 1 is a rare enol tautomer, and compound 2 an unusual phenethylamine alkaloid with a N-NO group.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology
  • Antibiotics, Antineoplastic / chemistry
  • Antibiotics, Antineoplastic / pharmacology
  • Antifungal Agents / pharmacology
  • Cell Line, Tumor
  • Chromatography, Thin Layer
  • Ethylamines / chemistry*
  • Ethylamines / isolation & purification
  • Ethylamines / pharmacology
  • Fermentation
  • Fusarium / drug effects
  • Humans
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Microbial Sensitivity Tests
  • Phenethylamines / chemistry*
  • Phenethylamines / isolation & purification
  • Streptomyces / chemistry*
  • Streptomyces / growth & development

Substances

  • (S)-N-nitroso-1-amino-p-hydroxy phenylethanol
  • Alkaloids
  • Antibiotics, Antineoplastic
  • Antifungal Agents
  • Ethylamines
  • Phenethylamines