Abstract
We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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Boronic Acids / chemistry*
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HIV-1 / genetics
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HIV-1 / metabolism
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Humans
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Peptide Library
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Peptides / chemistry*
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Peptides / metabolism
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Protein Binding
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RNA, Viral / metabolism*
Substances
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Boronic Acids
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Peptide Library
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Peptides
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RNA, Viral