Branched peptide boronic acids (BPBAs): a novel mode of binding towards RNA

Chem Commun (Camb). 2013 Mar 25;49(24):2436-8. doi: 10.1039/c3cc00243h.

Abstract

We report branched peptide boronic acids (BPBAs) that bind to RRE IIB from an on-bead high-throughput screening of a 3.3.4-library (46 656 compounds). We demonstrate that boronic acids are tunable moieties that afford a novel binding mode towards RNA.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Boronic Acids / chemistry*
  • HIV-1 / genetics
  • HIV-1 / metabolism
  • Humans
  • Peptide Library
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Binding
  • RNA, Viral / metabolism*

Substances

  • Boronic Acids
  • Peptide Library
  • Peptides
  • RNA, Viral