HIF proteins connect the RB-E2F factors to angiogenesis

Transcription. 2013 Mar-Apr;4(2):62-6. doi: 10.4161/trns.23680. Epub 2013 Feb 14.

Abstract

Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. (1) Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.

Keywords: E2F; HIF; RB; VEGF; angiogenesis; cancer; hypoxia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • E2F Transcription Factors / deficiency
  • E2F Transcription Factors / genetics
  • E2F Transcription Factors / metabolism*
  • Humans
  • Hypoxia-Inducible Factor 1 / metabolism*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neovascularization, Pathologic
  • Receptors, Vascular Endothelial Growth Factor / metabolism
  • Repressor Proteins / metabolism*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • E2F Transcription Factors
  • Hypoxia-Inducible Factor 1
  • Repressor Proteins
  • Vascular Endothelial Growth Factor A
  • Receptors, Vascular Endothelial Growth Factor