Abstract
A new butenolide isoaspulvinone E (1), together with two known butenolides aspulvinone E (2) and pulvic acid (3) were isolated from the marine-derived fungus, Aspergillus terreus Gwq-48. They showed significant anti-influenza A H1N1 virus activities, with IC50 values of 32.3, 56.9, and 29.1μg/mL, respectively. Moreover, only compound 1 exhibited effective inhibitory activity against H1N1 viral neuraminidase (NA), and docking of two isomers (1-2) into the active sites of NA showed that the E double bond Δ(5(10)) was essential to achieve activity.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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4-Butyrolactone / analogs & derivatives*
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4-Butyrolactone / chemistry
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4-Butyrolactone / isolation & purification
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4-Butyrolactone / pharmacology
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Animals
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Antiviral Agents / chemistry*
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Antiviral Agents / isolation & purification
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Antiviral Agents / pharmacology
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Aspergillus / isolation & purification
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Aspergillus / metabolism*
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Benzylidene Compounds / chemistry*
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Benzylidene Compounds / isolation & purification
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Benzylidene Compounds / pharmacology
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Binding Sites
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Catalytic Domain
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Cell Line
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Cell Survival / drug effects
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Dogs
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Humans
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Influenza A Virus, H1N1 Subtype / drug effects
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Influenza A Virus, H1N1 Subtype / metabolism*
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Molecular Docking Simulation
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Neuraminidase / antagonists & inhibitors*
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Neuraminidase / metabolism
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Rhizosphere
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Soil Microbiology
Substances
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Antiviral Agents
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Benzylidene Compounds
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isoaspulvinone E
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butenolide
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Neuraminidase
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4-Butyrolactone