Detection of plasmid-mediated quinolone resistance determinants and the emergence of multidrug resistance in clinical isolates of Shigella in SiXian area, China

Diagn Microbiol Infect Dis. 2013 Mar;75(3):327-9. doi: 10.1016/j.diagmicrobio.2012.12.001.

Abstract

A total of 123 Shigella isolates were collected from SiXian area in Anhui, China. Screening was carried out by polymerase chain reaction (PCR) amplification of plasmid-mediated quinolone resistance (PMQR) determinants. Different β-blactamases genes, plasmid-borne bla(AmpC), 16S rRNA methylase genes, integrons, and mutations in quinolone resistance-determining regions were analysed by PCR for the PMQR-positive isolates.

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacterial Proteins / genetics
  • China / epidemiology
  • Ciprofloxacin / pharmacology*
  • DNA Gyrase / genetics
  • DNA Topoisomerase IV / genetics
  • Drug Resistance, Multiple, Bacterial*
  • Dysentery, Bacillary / epidemiology
  • Dysentery, Bacillary / microbiology
  • Genes, Bacterial
  • Genes, rRNA
  • Humans
  • Integrons
  • Mutation
  • Plasmids / genetics*
  • Polymerase Chain Reaction / methods
  • RNA, Ribosomal, 16S / genetics
  • Shigella / drug effects*
  • Shigella / genetics
  • Shigella / isolation & purification
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • RNA, Ribosomal, 16S
  • Ciprofloxacin
  • AmpC beta-lactamases
  • beta-Lactamases
  • DNA Topoisomerase IV
  • DNA Gyrase