Abstract
Objective:
The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.
Materials and methods:
We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.
Results:
Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Animals
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Biomarkers, Tumor / blood*
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Carcinoma, Non-Small-Cell Lung / blood*
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Carcinoma, Non-Small-Cell Lung / genetics
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Carcinoma, Non-Small-Cell Lung / metabolism
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Carcinoma, Non-Small-Cell Lung / mortality
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Cell Line, Tumor
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Female
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Gene Expression
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Humans
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Lung Neoplasms / blood*
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Lung Neoplasms / genetics
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Lung Neoplasms / metabolism
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Lung Neoplasms / mortality
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Male
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Mice
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Middle Aged
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Neoplasm Staging
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Neoplasm Transplantation
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Peptide Fragments / blood*
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Peptide Fragments / genetics
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Peptide Fragments / metabolism
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Predictive Value of Tests
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Prognosis
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Protein Structure, Tertiary
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Proto-Oncogene Proteins c-met / blood*
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Proto-Oncogene Proteins c-met / genetics
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Proto-Oncogene Proteins c-met / metabolism
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Solubility
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Survival Analysis
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Tumor Burden
Substances
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Biomarkers, Tumor
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Peptide Fragments
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Proto-Oncogene Proteins c-met