Shedding of c-Met ectodomain correlates with c-Met expression in non-small cell lung cancer

Biomarkers. 2013 Mar;18(2):126-35. doi: 10.3109/1354750X.2012.751455.

Abstract

Objective: The aim of this study is to reveal the correlation of shedding and expression of c-Met in non-small cell lung cancer (NSCLC) patient.

Materials and methods: We measured soluble c-Met and c-Met level in a panel of pre-clinical models and 197 advanced Chinese NSCLC patients by enzyme-linked immunosorbent assay and immunohistochemistry, respectively.

Results: Shedding of soluble c-Met associates with total c-Met amount in pre-clinical models, and soluble c-Met correlates with both c-Met expression level and tumor size in human, high soluble c-Met predicts poorer outcome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Animals
  • Biomarkers, Tumor / blood*
  • Biomarkers, Tumor / genetics
  • Biomarkers, Tumor / metabolism
  • Carcinoma, Non-Small-Cell Lung / blood*
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / metabolism
  • Carcinoma, Non-Small-Cell Lung / mortality
  • Cell Line, Tumor
  • Female
  • Gene Expression
  • Humans
  • Lung Neoplasms / blood*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / metabolism
  • Lung Neoplasms / mortality
  • Male
  • Mice
  • Middle Aged
  • Neoplasm Staging
  • Neoplasm Transplantation
  • Peptide Fragments / blood*
  • Peptide Fragments / genetics
  • Peptide Fragments / metabolism
  • Predictive Value of Tests
  • Prognosis
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-met / blood*
  • Proto-Oncogene Proteins c-met / genetics
  • Proto-Oncogene Proteins c-met / metabolism
  • Solubility
  • Survival Analysis
  • Tumor Burden

Substances

  • Biomarkers, Tumor
  • Peptide Fragments
  • Proto-Oncogene Proteins c-met