No viral evolution in the lymph nodes of simian immunodeficiency virus-infected rhesus macaques during combined antiretroviral therapy

J Virol. 2013 Apr;87(8):4789-93. doi: 10.1128/JVI.03367-12. Epub 2013 Feb 13.

Abstract

To elucidate the mode of viral persistence in primate lentivirus-infected individuals during combination antiretroviral therapy (cART), four simian immunodeficiency virus 239-infected monkeys were treated with cART for 1 year. The viral env genes prepared from total RNA extracted from the mesenteric lymph nodes collected at the completion of therapy were assessed by single genome amplification. Analyses of nucleotide substitutions and phylogeny revealed no viral evolution during cART.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Retroviral Agents / administration & dosage*
  • Antiretroviral Therapy, Highly Active
  • Evolution, Molecular*
  • Gene Products, env / genetics
  • Lymph Nodes / virology*
  • Macaca mulatta
  • Phylogeny
  • Point Mutation
  • Sequence Analysis, DNA
  • Simian Acquired Immunodeficiency Syndrome / drug therapy*
  • Simian Acquired Immunodeficiency Syndrome / virology*
  • Simian Immunodeficiency Virus / classification*
  • Simian Immunodeficiency Virus / genetics*
  • Simian Immunodeficiency Virus / isolation & purification

Substances

  • Anti-Retroviral Agents
  • Gene Products, env