The bis(indolyl)imidazole alkaloid nortopsentin a exhibits antiplasmodial activity

Antimicrob Agents Chemother. 2013 May;57(5):2362-4. doi: 10.1128/AAC.02091-12. Epub 2013 Feb 12.

Abstract

A library of enriched marine natural product fractions was screened for their antiplasmodial activity using a SYBR green I fluorescence-based assay. Fractions derived from a sponge of the genus Spongosorites exhibited potent inhibition of Plasmodium falciparum growth. This genus of sponge has been reported to contain the nortopsentin and topsentin class of bis-indole imidazole alkaloids. This is the first report of nortopsentin A inhibiting parasite growth at the trophozoite stage at submicromolar 50% inhibitory concentrations (IC(50)).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Animals
  • Antimalarials / isolation & purification
  • Antimalarials / pharmacology*
  • Erythrocytes / drug effects
  • Erythrocytes / parasitology
  • Humans
  • Imidazoles / isolation & purification
  • Imidazoles / pharmacology*
  • Indoles / isolation & purification
  • Indoles / pharmacology*
  • Inhibitory Concentration 50
  • Plasmodium falciparum / drug effects*
  • Plasmodium falciparum / growth & development
  • Porifera / chemistry*
  • Small Molecule Libraries / isolation & purification
  • Small Molecule Libraries / pharmacology*
  • Trophozoites / drug effects*
  • Trophozoites / growth & development

Substances

  • Alkaloids
  • Antimalarials
  • Imidazoles
  • Indoles
  • Small Molecule Libraries
  • topsentin A