Anti-atherosclerotic mechanisms of statin therapy

Andrea Babelova; Daniel G Sedding; Ralf P Brandes

doi:10.1016/j.coph.2013.01.004

Anti-atherosclerotic mechanisms of statin therapy

Curr Opin Pharmacol. 2013 Apr;13(2):260-4. doi: 10.1016/j.coph.2013.01.004. Epub 2013 Feb 9.

Authors

Andrea Babelova¹, Daniel G Sedding, Ralf P Brandes

Affiliation

¹ Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Frankfurt, Germany.

PMID: 23402735
DOI: 10.1016/j.coph.2013.01.004

Abstract

HMG-CoA-Reductase inhibitors, also known as statins, are currently the most powerful cholesterol-lowering drugs available on the market. Clinical trials and experimental evidence suggest that statins have anti-atherosclerotic effects. These are in part consequence of lipid lowering but also result from pleiotropic actions of the drugs. In this article, the anti-atherosclerotic actions of statins will be reviewed.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
Hypercholesterolemia / drug therapy*
Hypercholesterolemia / metabolism
Hypercholesterolemia / physiopathology

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors