Analysis and modeling of an ultrasound-modulated guide star to increase the depth of focusing in a turbid medium

J Biomed Opt. 2013 Feb;18(2):25004. doi: 10.1117/1.JBO.18.2.025004.

Abstract

The effects of strong scattering in tissue limit the depth to which light may be focused. However, it has been shown that scattering may be reduced utilizing adaptive optics with a focused ultrasound (US) beam guidestar. The optical signal traveling through the US beam waist is frequency shifted and may be isolated with demodulation. This paper utilizes a multiphysics simulation to model the optical and US interactions in both synthetic tissue and random scattering media. The results illustrate that optical energy may be focused within a turbid medium utilizing a US guidestar. The results also suggest that optical energy travels preferentially along optical channels within a turbid medium.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Algorithms
  • Computer Simulation
  • Models, Biological
  • Nephelometry and Turbidimetry
  • Optical Imaging / methods*
  • Optical Imaging / statistics & numerical data
  • Optical Phenomena
  • Phantoms, Imaging
  • Scattering, Radiation
  • Skin / anatomy & histology
  • Titanium
  • Ultrasonics

Substances

  • titanium dioxide
  • Titanium