Abstract
Intestinal mononuclear phagocytes have collectively emerged as key players in the maintenance of gut homeostasis, the development of gut inflammation and its resolution. Moreover, recent intense research efforts of many laboratories have revealed evidence for critical labor division between lamina propria-resident CD103(+) dendritic cells and CX3CR1(+) macrophages. In depth understanding of the respective activities of these cells in the mucosal landscape might pave the way for novel treatments of inflammatory bowel disorders (IBD).
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Animals
-
Antigens, CD / immunology
-
CX3C Chemokine Receptor 1
-
Dendritic Cells / immunology*
-
Dendritic Cells / pathology
-
Homeostasis / immunology*
-
Humans
-
Immunity, Mucosal*
-
Inflammatory Bowel Diseases / immunology*
-
Inflammatory Bowel Diseases / pathology
-
Integrin alpha Chains / immunology
-
Intestinal Mucosa / immunology*
-
Intestinal Mucosa / pathology
-
Macrophages / immunology*
-
Macrophages / pathology
-
Receptors, Chemokine / immunology
Substances
-
Antigens, CD
-
CX3C Chemokine Receptor 1
-
CX3CR1 protein, human
-
Integrin alpha Chains
-
Receptors, Chemokine
-
alpha E integrins