Abstract
Understanding the pathogenesis of an infectious disease is critical for developing new methods to prevent infection and diagnose or cure disease. Adherence of microorganisms to host tissue is a prerequisite for tissue invasion and infection. Fungal cell wall adhesins involved in adherence to host tissue or abiotic medical devices are critical for colonization leading to invasion and damage of host tissue. Here, with a main focus on pathogenic Candida species, we summarize recent progress made in the field of adhesins in human fungal pathogens and underscore the importance of these proteins in establishment of fungal diseases.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Amino Acid Sequence
-
Candida / genetics*
-
Candida / metabolism
-
Candida / pathogenicity
-
Candidiasis / microbiology
-
Cell Adhesion
-
Cell Adhesion Molecules / genetics*
-
Cell Adhesion Molecules / metabolism
-
Cell Wall / genetics
-
Cell Wall / metabolism
-
Fungal Proteins / genetics*
-
Fungal Proteins / metabolism
-
Gene Expression Regulation, Fungal*
-
Host-Pathogen Interactions
-
Humans
-
Membrane Glycoproteins / genetics*
-
Membrane Glycoproteins / metabolism
-
Molecular Sequence Data
-
Multigene Family
-
Protein Structure, Secondary
-
Protein Structure, Tertiary
Substances
-
ALA1 protein, Candida albicans
-
Cell Adhesion Molecules
-
Fungal Proteins
-
HWP1 protein, Candida albicans
-
Membrane Glycoproteins