Total synthesis of kottamide E

Chem Commun (Camb). 2013 Mar 21;49(23):2296-8. doi: 10.1039/c3cc39062d.

Abstract

The first synthesis of kottamide E, a marine natural product containing a 5,6-dibromoindole linked via a (Z)-enamide to an unusual 1,2-dithiolane-containing amino acid, is reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemical synthesis
  • Amino Acids / chemistry*
  • Indole Alkaloids / chemical synthesis*
  • Indole Alkaloids / chemistry
  • Indoles / chemistry
  • Thioctic Acid / analogs & derivatives*
  • Thioctic Acid / chemistry

Substances

  • 1,2-dithiolane
  • Amino Acids
  • Indole Alkaloids
  • Indoles
  • kottamide E
  • indole-3-carboxylic acid
  • Thioctic Acid
  • indole