Abstract
A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested.
Copyright © 2013 Elsevier Ltd. All rights reserved.
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / toxicity
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Cell Line, Tumor
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Cell Proliferation / drug effects
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DNA / chemistry
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DNA / metabolism
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Indazoles / chemistry*
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Mitoxantrone / chemistry
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Mitoxantrone / toxicity
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Quinolones / chemical synthesis
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Quinolones / chemistry*
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Quinolones / toxicity
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S Phase Cell Cycle Checkpoints / drug effects
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Indazoles
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Quinolones
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DNA
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Mitoxantrone