Synthesis of novel aryl and heteroaryl acyl sulfonimidamides via Pd-catalyzed carbonylation using a nongaseous precursor

Sanjay R Borhade; Anja Sandström; Per I Arvidsson

doi:10.1021/ol400049m

Synthesis of novel aryl and heteroaryl acyl sulfonimidamides via Pd-catalyzed carbonylation using a nongaseous precursor

Org Lett. 2013 Mar 1;15(5):1056-9. doi: 10.1021/ol400049m. Epub 2013 Feb 8.

Authors

Sanjay R Borhade¹, Anja Sandström, Per I Arvidsson

Affiliation

¹ Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.

PMID: 23394148
DOI: 10.1021/ol400049m

Abstract

Hitherto unexplored aryl and heteroaryl acyl sulfonimidamides have been prepared through the development of a new Pd-catalyzed carbonylation protocol. This novel methodology, employing sulfonimidamides as nucleophiles and CO gas ex situ released from solid Mo(CO)6 in a sealed two-chamber system, yields a wide range of carbamate protected acyl sulfonimidamides in good to excellent yields.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Molecular Structure
Palladium / chemistry*
Sulfur Compounds / chemical synthesis*
Sulfur Compounds / chemistry*

Substances

Sulfur Compounds
Palladium