In vitro antifungal susceptibility of Cladophialophora carrionii, an agent of human chromoblastomycosis

S Deng; G S de Hoog; H Badali; L Yang; M J Najafzadeh; B Pan; I Curfs-Breuker; J F Meis; W Liao

doi:10.1128/AAC.02114-12

In vitro antifungal susceptibility of Cladophialophora carrionii, an agent of human chromoblastomycosis

Antimicrob Agents Chemother. 2013 Apr;57(4):1974-7. doi: 10.1128/AAC.02114-12. Epub 2013 Feb 4.

Authors

S Deng¹, G S de Hoog, H Badali, L Yang, M J Najafzadeh, B Pan, I Curfs-Breuker, J F Meis, W Liao

Affiliation

¹ Shanghai Institute of Medical Mycology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Abstract

A global collection of Cladophialophora carrionii strains (n = 81) was tested against nine antifungal drugs. MIC90s of all strains were as follows in increasing order: itraconazole and posaconazole, 0.063 μg/ml; terbinafine, 0.125 μg/ml; isavuconazole and voriconazole, 0.25 μg/ml; caspofungin, 2 μg/ml; micafungin, 4 μg/ml; amphotericin B, 8 μg/ml; and fluconazole, 64 μg/ml.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amphotericin B / pharmacology
Antifungal Agents / pharmacology*
Ascomycota / drug effects*
Ascomycota / pathogenicity*
Caspofungin
Chromoblastomycosis / microbiology*
Echinocandins / pharmacology
Lipopeptides / pharmacology
Micafungin
Microbial Sensitivity Tests
Nitriles / pharmacology
Pyridines / pharmacology
Pyrimidines / pharmacology
Triazoles / pharmacology
Voriconazole

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Nitriles
Pyridines
Pyrimidines
Triazoles
isavuconazole
posaconazole
Amphotericin B
Caspofungin
Voriconazole
Micafungin