The risk factors of mild decline in estimated glomerular filtration rate in a community-based population

Abstract

Objectives: The study aimed to analyze the relationship between metabolic variables and estimated glomerular filtration rate (eGFR) and explore the potential risk factors for a mildly reduced eGFR in a community-based population.

Design and methods: Cross-sectional study in 643 adults without a history of kidney disease whose eGFR levels were greater than 60 mL/min/1.73 m(2) according to the Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). Anthropometric measurements, blood pressure, fasting lipid profile and levels of fasting and post-load glucose, insulin, serum creatinine and uric acid (UA) were tested. The eGFR was calculated, and the correlations between eGFR and each variable were analyzed.

Results: The subjects were divided into two groups by using 90 mL/min/1.73 m(2) as the cut-off value of the eGFR. In the lower eGFR group, the age, systolic blood pressure (SBP), diastolic blood pressure (DBP), body mass index (BMI), waist circumference (WC), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), 2 h post-load plasma glucose (2 h-PG) levels and UA were significantly increased, and the incidences of hypertension, diabetes, obesity, hypertriglyceridemia and hypercholesterolemia were also higher (P<0.05). A multiple linear stepwise regression analysis showed that the WC, SBP, FPG and UA were independently correlated with the eGFR after adjusting for the other covariables.

Conclusions: The WC, SBP, FPG and UA were closely related to the eGFR in the subjects whose eGFR levels were greater than 60 mL/min/1.73 m(2). The increased WC, SBP, FPG and UA may be the main risk factors for a mildly reduced eGFR.