Abstract
A series of s-triazolobenzothiazolylthioacetyl/propionyl amino acid derivatives were synthesized with the aim of evaluating their antifungal activity. Their chemical structures were confirmed by (1)H, (13)C NMR, IR, mass spectrometry and elemental analyses. The synthesized derivatives were screened for their antifungal activity against Aspergillus flavus and Candida albicans. Five compounds (3, 5, 7c, 8 and 17) were found to possess high activity comparable to fluconazole at 100 μg/mL against C. albicans.
Copyright © 2012 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Amino Acids / chemical synthesis
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Amino Acids / chemistry
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Amino Acids / pharmacology*
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Antifungal Agents / chemical synthesis
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology*
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Aspergillus flavus / drug effects*
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Benzothiazoles / chemical synthesis
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Benzothiazoles / chemistry
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Benzothiazoles / pharmacology*
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Candida albicans / drug effects*
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Dose-Response Relationship, Drug
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Microbial Sensitivity Tests
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Molecular Structure
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Structure-Activity Relationship
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Triazoles / chemical synthesis
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Triazoles / chemistry
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Triazoles / pharmacology*
Substances
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Amino Acids
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Antifungal Agents
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Benzothiazoles
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Triazoles