M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

Retrovirology. 2013 Feb 1:10:12. doi: 10.1186/1742-4690-10-12.

Abstract

Background: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen.

Findings: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding.

Conclusions: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-HIV Agents / metabolism*
  • Biomimetics*
  • CD4 Antigens / metabolism*
  • Disease Transmission, Infectious / prevention & control
  • Female
  • HIV Envelope Protein gp120 / antagonists & inhibitors*
  • HIV Infections / prevention & control
  • HIV Infections / transmission
  • HIV-1 / drug effects*
  • Humans
  • Leukocytes, Mononuclear / drug effects
  • Leukocytes, Mononuclear / virology
  • Mucous Membrane / virology
  • Vagina / virology
  • Virion / drug effects*

Substances

  • Anti-HIV Agents
  • CD4 Antigens
  • HIV Envelope Protein gp120
  • gp120 protein, Human immunodeficiency virus 1